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Changzhi Sanbao Biochemical Pharmaceutical Co., Ltd.

Mecobalaminum, Mecobalamin, Mecobalamina manufacturer / supplier in China, offering Mecobalaminum (Vitamin B12) Injection Mecobalamin Injection Cyanocobalamin Injection, Adenosine CAS 58-61-7 for injection Antiviral Agents, GMP Certificated Pharmaceutical Drugs, High Quality Calcium Chloride Injection 10ml and so on.

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Supplier Homepage Product Injection Mecobalaminum (Vitamin B12) Injection Mecobalamin Injection Cyanocobalamin Injection

Mecobalaminum (Vitamin B12) Injection Mecobalamin Injection Cyanocobalamin Injection

FOB Price: US $0.1-100 / BOX
Min. Order: 10,000 BOX
Min. Order FOB Price
10,000 BOX US $0.1-100/ BOX
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Port: Shanghai, China
Production Capacity: 50000box
Payment Terms: L/C, T/T, D/P, Western Union, Paypal, Money Gram

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Basic Info
  • Model NO.: injection
  • Usage Mode: I.M.
  • State: Liquid
  • Type: Organic Chemicals
  • Use: Injection
  • Trademark: sunbiolab
  • Specification: 2ml: 1mg
  • Application: Vitamin
  • Suitable for: Elderly, Children, Adult
  • Shape: AMP
  • Pharmaceutical Technology: Chemical Synthesis
  • Dosage: 2ml:1mg;2ml:0.5mg
  • Transport Package: Box
  • Origin: China
Product Description
WE CAN PROVIDE CDMO(OEM)
Product Description
Product nameVitam B12
Specifications2ml
CompositionVitamin B12 Each AMP
Package5 amps/box OR 10 amps/Box
StorageKeep out of reach of children
Store below 25oC Protect from light
Shlef lift36 month
RoutdFor I.M.

Mecobalaminum (Vitamin B12) Injection Mecobalamin Injection Cyanocobalamin Injection

DESCRIPTION:

 Cyanocobalamin Injection, USP is a sterile solution of cyanocobalamin for intramuscular or subcutaneous injection. Each mL contains 1000 mcg cyanocobalamin.

CLINICAL PHARMACOLOGY:

Vitamin B 12 is essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis.

Cyanocobalamin is quantitatively and rapidly absorbed from intramuscular and subcutaneous sites of injection; the plasma level of the compound reaches its peak within 1 hour after intramuscular injection. Absorbed vitamin B 12 is transported via specific B 12 binding proteins, transcobalamin I and II to the various tissues. The liver is the main organ for vitamin B 12 storage.

Within 48 hours after injection of 100 or 1000 mcg of vitamin B 12, 50 to 98% of the injected dose may appear in the urine. The major portion is excreted within the first eight hours. Intravenous administration results in even more rapid excretion with little opportunity for liver storage.

Gastrointestinal absorption of vitamin B 12 depends on the presence of sufficient intrinsic factor and calcium ions. Intrinsic factor deficiency causes pernicious anemia, which may be associated with subacute combined degeneration of the spinal cord. Prompt parenteral administration of vitamin B 12 prevents progression of neurologic damage.

he average diet supplies about 5 to 15 mcg/day of vitamin B 12 in a protein-bound form that is available for absorption after normal digestion. Vitamin B 12 is not present in foods of plant origin, but is abundant in foods of animal origin. In people with normal absorption, deficiencies have been reported only in strict vegetarians who consume no products of animal origin (including no milk products or eggs).

Vitamin B 12 is bound to intrinsic factor during transit through the stomach; separation occurs in the terminal ileum in the presence of calcium, and vitamin B 12 enters the mucosal cell for absorption. It is then transported by the transcobalamin binding proteins. A small amount (approximately 1% of the total amount ingested) is absorbed by simple diffusion, but this mechanism is adequate only with very large doses. Oral absorption is considered too undependable to rely on in patients with pernicious anemia or other conditions resulting in malabsorption of vitamin B 12.

Cyanocobalamin is the most widely used form of vitamin B 12, and has hematopoietic activity apparently identical to that of the antianemia factor in purified liver extract. Hydroxycobalamin is equally as effective as cyanocobalamin, and they share the cobalamin molecular structure.

INDICATIONS AND USAGE:

Cyanocobalamin is indicated for vitamin B 12 deficiencies due to malabsorption which may be associated with the following conditions:

  • Addisonian (pernicious) anemia
  • Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacteria overgrowth, total or partial gastrectomy
  • Fish tapeworm infestation
  • Malignancy of pancreas or bowel
  • Folic acid deficiency
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